3rd course on Multiscale Integration in Biological Systems – 2018November 7-13, 2018 / Institut Curie - Paris M. Coppey, M. Dahan, H. Isambert, P. Martin, P. Nghe, P. Sens, P. Silberzan, A. Walczak
Physical description of biological systems, from the single molecule to organisms.
Speakers: Anthony Hyman (DE), Karen Alim (DE), William Bialek (USA), Philippe Bousso (FR), Georges Debrégeas (FR), Barbara Di Ventura (DE), Stephan Grill (DE), Karine Guevorkian (FR), Liedwij Laan (NL), Suliana Manley (CH), Andrew Mugler (USA), Alexandre Morogov (USA), Philippe Nghe (FR), Armita Nourmohammad (DE), Agnese Seminara (FR), Pierre Sense (FR), Olivier Tenaillon (FR), Barbara Treutlein (DE), Erik Van Nimwegen (CH), Huyn Youk (NL).
One of the fundamental issues in biology is the understanding of the relationship between the multiple spatial and temporal scales observed in a biological system. From molecules to a cellular function, from a collection of cells to an organism, or from individuals to a population, the complex interactions between singular elements can give rise to “emergent” properties at the ensemble level. To what extent can the spatial and temporal order seen at the system level be explained by subscale properties?
During this previous course, most seminars were filmed. Discover videos here.
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Master2 students, PhD students and postdocs interested in the interface between physics and biology. (The course will provide 10 ECTS at some doctoral schools in Paris, e.g. ED PIF and ED FDV). Students or researchers can also audit the course without receiving credit.
Participants will be selected on the basis of their research interest (CV), motivation statement. Each participant will give a 20 min oral presentation on his/her work or will have the opportunity to give a flash presentation and a poster.
All lunches will be provided by Institut Curie. Participants’ home laboratories are responsible for paying travel and lodging. Institut Curie will pre-booked hotel rooms at preferential rates. A few fellowships will be available upon request and granted to the best presentations.
The course will give an overview of modern physical tools that have been developed to address the issue of scale integration (mornings) and will show how these tools can be applied to specific biological systems (afternoons).
– Non-linear physics, criticality / bistability, switches, oscillations, signal amplification.
– self-organization, collective phenomenon, phase transitions / pattern formation, flocks, cellular
– evolution, cooperativity and competition / population genetics, evolutionary approach of cancer.