The general objective of this 9th cytoskeleton course is to understand the role of the cytoskeleton in 3D systems at different levels: molecular, cellular and in the living organism. The course will provide introductions to the main cytoskeleton networks as well as to the main knowledge in force generation and tissue mechanics. The course will cover general mechanisms of cytoskeleton functions, in the organization and the maintenance of tissue shape and mechanics in different conditions, systems and organs: during development, on monolayers, in gut homeostasis, during the immunological response, in cancer and in the brain.
The Rosenblatt Lab studies both cell death and cell division and the roles that the actin and microtubule cytoskeletons play in both processes. Our lab is investigating if extrusion (a contraction that squeezes dying cells out of tissue) could drive cell death in order to control cell numbers.