Regulation of Microtubule Dynamics and Function

Carsten Janke
Scientific keywords: regulation of the microtubule cytoskeleton, tubulin heterogeneity, tubulin isoforms, tubulin polyglutamylation, tubulin polyglycylation, tubulin posttranslational modifications
Technics Used in the Lab: biochemistry, cell biology, crystallography, cell biology, microscopy, lentivirus, mouse biology, histochemistry, in vitro assays with microtubules

Our team is interested in the functional roles of microtubule heterogeneity. This heterogeneity can be generated by either the incorporation of different tubulin isoforms (isotypes) into the microtubule lattice, or by differential posttranslational modification of the assembled microtubules. Our current focus is to develop novel approaches to measure the impact of tubulin heterogeneity on microtubule functions. The approaches used on our lab range from biochemistry to cell biology and in vivo studies in mice.




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